A black Lexus struck a number of vehicles parked near the junction of Vista Road and Queens Road, Haydock at about 8.40pm on Wednesday.
The trail of damage caused to gardens and fences folllowing the crash
Four people were inside the Black Lexus car.
A rear seat passenger in the vehicle, a 19-year-old man, was taken to hospital, where he passed away.
His next of kin have been informed.
The driver of the vehicle, a 25-year-old man, and two other passengers - a 25-year-old man and a 26-year-old man - were all taken to hospital with serious injuries.
A police spokesman confirmed the teenager who died is from St Helens and the three men who are injured are from Newton-le-Willows.
The Lexus had been travelling north on Vista Road heading towards the East Lancs Road when it collided with a parked red Ford Connect van, a blue Ford Fiesta, a black Vauxhall Corsa.
It then entered front gardens of a number of properties before colliding with a grey Vauxhall Mokka.
A police spokesman said: "We are appealing for anyone who was travelling along Vista Road last night who saw the Lexus prior to the collision to contact us.
"We would also ask anyone who may have captured the car on dash-cam footage to get in touch as they may have information which is vital to our investigation.
"Anyone with information is asked to call the Matrix Roads Policing Unit on 0151 777 5747 or DM @MerPolCC or 101 quoting reference 19100724889."
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